Despite a career-high 34 points from Makenna Marisa, the Lady Lions dropped their second game in a row.
The Nittany Lions punched their ticket to the Sweet 16 with the help of 16 kills from Zoe Weatherington.
The Nittany Lions went 0-for-5 on the man advantage in the loss.
Josie Bothun recorded her fifth shutout of the season and Kiara Zanon grabbed three points in a one-sided shutout.