It was the team's fourth overtime loss of the season and second-straight loss.
Roman Bravo-Young, Shayne Van Ness, and Carter Starocci all scored bonus point wins, but the stars of the afternoon were Levi Haines, Alex Facundo, and Seth Nevills.
The Nittany Lions failed to answer Villanova's two late goals as they lost their first game of the season.
Penn State's depth didn't show up against Saint Francis, but John Kerr led the momentum to spark the 3-2 comeback victory.
The Bucknell Bison had just 11 shots on goal as the Nittany Lions defense held them back all game long.
Freshman Kanye Clary set a new career high with 17 points, but the Nittany Lions were unable to sneak out of College Park with a win.