Despite an early lead, Penn State fell apart in the second half, and Maryland secured a fourth quarter comeback win.
The Nittany Lions now have consecutive Big Ten series wins to open a season for the first time since 2016.
The Nittany Lions were swept for the first time all season.
The victory puts the Nittany Lions on the brink of clinching the EIVA conference.
The Nittany Lions rallied from a five-run deficit to secure the victory at Beard Field on Saturday.
Nzeh finished his lone year with the Musketeers with 47 points, 47 rebounds, and seven blocks.