Penn State arrived in College Park, Maryland, with five No. 1 seeds and no wrestler ranked lower than the No. 6 seed.
Head coach Mike Gambino won his 300th career game during the series.
Aaron Nagao and Tyler Kasak will now wrestle for third place in session four.
The Nittany Lions were automatic qualifiers after clinching the CHA Championship.
Three Nittany Lions will advance to their first championship appearances.
A strong second period wasn't enough for Penn State to extend its Big Ten Tournament hopes after a late goal from Minnesota.