Ace Baldwin Jr. had 18 points in the second half to lead the Nittany Lions past the Hawkeyes.
The Nittany Lions have an overall .500 record with just nine regular season games ahead of the Big Ten Tournament.
Without leading scorer Kayne Clary, Penn State earned its first road win of the season thanks to great defensive play.
"It's very special, where you have a team that buys into the success of those around them because when they do that, their success rises, too."
"One day, our vision is that they look at Penn State as a target school. Not just a school where they can recruit from, but one where they should recruit from."
The Nittany Lions defeated the top-ranked Buckeyes for the second time in three days.