The Nittany Lions had just two hits in nine innings.
The Lady Lions are headed to the semifinals after an energetic win in the last home game of the season.
Penn State scored 46 points in the paint to advance to the semifinals.
The Lady Lions will play Mississippi State in the quarterfinals of the WBIT after winning two close games.
The four-point overtime victory came after Penn State was down by 12 points in the fourth quarter.
All of the injured Nittany Lions expect a full recovery from their injuries before the NFL Draft.