The Mustangs have one of the most dangerous offenses in college football.
There will be some different procedures than usual, including SMU's hype video being shown before the game.
Hudson, who is the Nittany Lions' first transfer portal addition, scored a touchdown against Penn State this season.
Pribula's decision came less than a week before Penn State's College Football Playoff tilt against SMU.
Seifarth has dazzled early in his Division I career.
Cunningham didn't see any action this season.