Midfielder Caden Grabfelder was selected by CF Montreal, while defender Mohamed Cisset heads to FC Dallas.
The Nittany Lions will play 26 games at home.
The Lady Lions extended their all-time series lead against the Friars to 8-0 behind Gracie Merkle's monstrous night.
Jess Mruzik's 21 kills and outstanding defensive showing elevated the Nittany Lions to the third round.
Penn State suffered through miscues on both sides of the ball to drop its second consecutive game.
The future Nittany Lions running back dominated on both sides of the ball in his junior year.