The Nittany Lions fall to 13-1 in conference play this season.
Brezina totaled 51 tackles, three tackles for loss, one forced fumble, and one fumble recovery across his Cyclone career.
Penn State has now lost at The Palestra two years in a row.
The Lady Lions recorded 18 offensive rebounds in the game.
Penn State is the only team to score 70+ points against Michigan State this season.
A coaching search that provided no coach for nearly two months somehow produced $370 million for everyone else.