The center will shift University Park's daily student surveillance testing from Vault Health to an in-house operation.
The quarantine, which retroactively dates back to Friday, September 4, will last until at least Saturday, September 14.
"I ask that you not travel over this holiday weekend, have visitors from out of town or attend parties or barbecues."
Penn State will refer to "asymptomatic testing" as "random screening" and "symptomatic testing" as "on-demand testing" moving forward.
On Tuesday, 32 students tested positive, bringing University Park's total positive cases to 174 cases on the week.
The new figures bring Athletics’ cumulative positive cases to 11 this summer.