Penn State scored nine points in the final frame and failed to score from the field in the last 6:11.
A two-skater breakaway led to an overtime winner for the Nittany Lions.
Janecke's 141 career points are the most in men's and women's program history.
The Nittany Lions couldn't complete the comeback despite pulling to within one in the final minute.
Penn State battled back from a 3-0 deficit to stun the Buckeyes in the shootout.
The Nittany Lions hope to rebound against the Buckeyes in their final matchup of the season.