Kaitlyn MacBean scored her 14th goal of the season in the regular season finale.
The Nittany Lions dropped their third game in a row in their final regular season match at Jeffrey Field.
Arsenii Sergeev made 25 saves en route to the Nittany Lions securing a series sweep.
Penn State earns third place in the Ice Breaker Tournament.
The Nittany Lions weathered a hectic start to come back and defeat St. Lawrence in their return to Pegula.
Lauren Delgado's nine saves were not enough to secure the win for the Nittany Lions.