Pitching struggled throughout the series as Penn State burned through 11 arms and allowed 25 runs over the three games.
Dane Dowiak's two goals guided the Nittany Lions to win a close game in Columbus.
The Nittany Lions coughed up a 23-point lead in the final road game of the regular season.
A first period conversion by Mya Vaslet was the game-winner for the Nittany Lions.
After scoring only two goals in the first half, TJ Malone and the Nittany Lions came back to win in sudden death overtime.
The Nittany Lions took their second road loss of the season after a gritty effort against Loyola.