Kailtyn MacBean recorded her 10th goal of the season in the win.
The Lady Lions begin Big Ten play on December 7 against Indiana.
The Nittany Lions will open Big Ten play against Purdue on December 5.
The Nittany Lions struggled heavily in front of the Panthers' home crowd.
Penn State's undefeated season came to an end.
The small forward became the second player to commit to the Nittany Lions.