Amelia White's early goal was not enough to overcome the Hawkeyes.
Penalties were an issue for both sides.
The Pistons will be Lamar Stevens' fourth team in his five-year NBA career.
This sweep marked Penn State third win against a top-10 team this season.
The Nittany Lions will face Ohio State on January 30, while the Lady Lions will face Maryland on January 29.
The NIttany Lions begin conference play with a top-10 matchup against Purdue Wednesday.