Aiden Fink is the only Penn State player on a preseason team.
Kailtyn MacBean recorded her 10th goal of the season in the win.
The Lady Lions begin Big Ten play on December 7 against Indiana.
The Nittany Lions will open Big Ten play against Purdue on December 5.
The Nittany Lions struggled heavily in front of the Panthers' home crowd.
Penn State's undefeated season came to an end.