Payton Linnehan, Penelope Hocking, Cori Dyke, and Amelia White each scored on Friday night to send the Nittany Lions to the Sweet Sixteen of the NCAA Tournament.
Down by 17 points at one point, the Nittany Lions cut the lead down to two points but ultimately could not get the win.
Penn State finishes the year 17-4 with a share of the Big Ten regular season title.
The Nittany Lions will play 26 non-conference games and 19 games in Happy Valley.
The Nittany Lions staved off a late-game push from Furman thanks to Jalen Pickett and Seth Lundy's offensive prowess.
Under Pennsylvania House Bill 2633, Penn State can now legally work with its student-athletes to secure NIL deals.