"We know we can play with those big teams no matter what."
Jalen Pickett led the way with 23 points, followed by Andrew Funk's 22-point Penn State debut.
The first-round matchup is scheduled for 1 p.m. on Sunday, November 13.
The Nittany Lions jumped five spots in the latest USCHO Poll following a series split against Michigan.
The Nittany Lions grabbed four of six possible points against the No. 1 team in the country.
Ally Schlegel scored a brace to lift the Nittany Lions to victory in the back-and-forth match.