After tying up the game in the third period, the Nittany Lions let up a late goal that proved to be the difference in Saturday's contest.
Penn State's new transfers, Ashton Calder and Ture Linden, were instrumental in the team's 5-2 defeat of Canisius.
The Nittany Lions dropped their third conference matchup of the season Friday night against Ohio State.
A four-goal first half, with two from Liam Butts, was all the Nittany Lions needed, as they breezed past the Spartans.
The win ended a four-year losing streak to the Hawkeyes.
Two late-game defensive breakdowns derailed the Nittany Lions' top-10 upset bid.