Penn State quickly lost control against the Hoosiers despite Kai Phillips' early goal.
Penn State snapped its four-game win streak, dropping its Big Ten opener.
Both Penn State men's and women's basketball missed out on the tournaments last year.
The Lady Lions announced their 2025-26 conference schedule Thursday, featuring nine home games at the Bryce Jordan Center.
Nebraska scored the game-tying goal in the last thirty seconds of the match.
The Nittany Lions will play Michigan, Ohio State, and Rutgers twice.