The veteran safeties combined for 21 total tackles, two pass breakups, one tackle for loss, and a forced fumble.
Drew Allar's three touchdown passes silenced the Mountaineers in Morgantown.
Penn State will be without tight ends Kahlil Dinkins and Jerry Cross in its season opener.
Penn State opens its season at noon on Saturday in Morgantown, West Virginia.
Warren's ability to block and catch gives opponents headaches.
The Mountaineers are loaded with veterans on the offensive and defensive lines.