Two Friends are best known for their hour-long "Big Bootie" mixes and collaborations with artists.
Saturday's show will be Key's fourth College GameDay appearance.
The Nittany Lions have various ways to beat opponents.
Carter has 9.5 tackles-for-loss and four sacks in his first season at defensive edge.
"That's your kind of college," Travis Kelce said. "You'd like that place."
The program appeared to show script lettering replacing the normal block-styled letters.