The Nittany Lions scored 35 unanswered points after beginning the dual down by eight.
Less than a month after suffering a 41-point loss to the Hawkeyes, Penn State was blown out by 44 on Sunday.
No. 9 Penn State men's hockey lost 4-2 to No. 7 Ohio State after three third-period scores by the Buckeyes.
The Nittany Lions clinched the CHA regular-season championship with their win over Syracuse on Saturday.
The Nittany Lions kicked off their year strong with a definitive victory in the season's first game.
The Nittany Lions' 20-point victory over the Buckeyes Friday night marked the program's 40th consecutive win.