The Nittany Lions scored three goals in about four minutes to tie the game late in the third period.
This will be Penn State's fourth game on FOX this season.
The Hoosiers couldn't stop much of the Nittany Lions' offense, spearheaded by a trio of touchdowns from Kaytron Allen.
Clifford is making his ninth start of the season in Penn State's game against Indiana.
Here's everything you need to know about Penn State's clash with the Hoosiers.
Liam Souliere recorded his second consecutive shutout.