Isaac's stat line this season is impressive, totaling 12 tackles and five sacks through the Nittany Lions' first five games this season.
Kirwan has scored in every game this season, which has propelled him up the national statsheet.
“It’s not an easy thing to do, but if you believe, you can win games.”
The over-under is set at 46.5 points for Saturday's noon kickoff in Columbus.
With over 34 million followers, Richards is one of the biggest influencers in the world and a host of the popular Barstool Sports podcast “BFFs”.
Our football writers broke down the hottest Penn State takes with perhaps its biggest game of the season ahead.