The Nittany Lions (18-37) upset No. 23 Nebraska 8-7 Thursday on Nick Riotto's walk-off double before losing the last two games of the season to the Cornhuskers.
Penn State exploded for nine unanswered runs Tuesday evening at Medlar Field, including a seven-run bottom of the eighth, in its final non-conference game of the regular season.
Rob Cooper's Nittany Lions opened the weekend with a 5-2 win in Bloomington, but fell to the Hoosiers 5-2 and 10-2 on Saturday and Sunday.
Missy Doherty's Nittany Lions (16-3) opened up a quick 8-1 lead over the Dukes, but would need a clutch showing to hold off the rally and advance.
Penn State upset the Mountaineers 6-5 in Morgantown Tuesday before dropping a 4-2 contest the following night at PNC Park.
Minnesota nearly doubled up the Nittany Lions in terms of production at the plate, tallying 45 hits to Penn State's 23 over the weekend at Medlar Field.