The Nittany Lions kicked off the 2025 campaign with a loss in Chicago, Illinois.
The Nittany Lions have won 63 straight duals.
Penn State falls to 1-9-1 in Big Ten conference play.
Katie DeSa recorded her fourth shutout of the season.
The group was targeted five times.
The defensive front was challenged and answered Notre Dame's top rushing attack. But in the end, it wasn't enough.