Wide receiver Malick Meiga and Trey Wallace could both miss Saturday's matchup.
The Nittany Lions will kick off against the Wildcats at noon on the Big Ten Network.
The Nittany Lions have gone 9-0 in their last nine sets to extend their conference win streak to three.
The Huskies spoiled Penn State's banner night and home opener with a shutout of the Nittany Lions.
The event will be hosted from 11 a.m. to 7 p.m. on Saturday, September 30, on the 100 block of South Fraser Street.
Folks can participate in a Penn State-Northwestern watch party at 11:30 a.m. in the HUB's Alumni Hall.