The Nittany Lions had more errors than hits in the loss.
Nwosu was Penn State's kickoff specialist for the last four seasons.
The two-time team captain will look for a new home at the next level.
Shelton was a two-year full-time starter for the Nittany Lions.
The Nittany Lions are now 26-12 and have won six of their last seven.
Danica Maynard was named to the All-USCHO Third and Rookie Team, while Tessa Janecke is now the first Nittany Lion to be named to the All-USCHO First Team.