The Nittany Lions were mercy ruled for the second consecutive game.
The Nittany Lions had more errors than hits in the loss.
Nwosu was Penn State's kickoff specialist for the last four seasons.
The two-time team captain will look for a new home at the next level.
Shelton was a two-year full-time starter for the Nittany Lions.
The Nittany Lions are now 26-12 and have won six of their last seven.