The Nittany Lions bested the Eagles for the first time in program history to give Jeff Kampersal his 400th win.
Saquon Barkley and Micah Parsons dominated during week five of the NFL season.
Pickett is one of 11 players to earn the preseason honor.
Kentucky quarterback Will Levis tossed four touchdowns for the Wildcats in their 31-23 win over Northern Illinois.
Jahan Dotson and Micah Parsons are two of several Nittany Lions in the NFL to impress during week two.