The Nittany Lions trailed at the end of the first half.
Vilbert had a strip-sack in his first game in two seasons after an extended rehab process.
Running back Terion Stewart scored three touchdowns in week one.
Winston had 12 total tackles and a forced fumble in the Nittany Lions' 34-12 win.
Penn State couldn't have done much better in its 34-12 win over West Virginia.
The veteran safeties combined for 21 total tackles, two pass breakups, one tackle for loss, and a forced fumble.