Gabby Elliott's 26 points weren't enough for Penn State to overcome two separate 15-point deficits against the Ducks.
Midfielder Caden Grabfelder was selected by CF Montreal, while defender Mohamed Cisset heads to FC Dallas.
The Nittany Lions will play 26 games at home.
The Lady Lions extended their all-time series lead against the Friars to 8-0 behind Gracie Merkle's monstrous night.
Jess Mruzik's 21 kills and outstanding defensive showing elevated the Nittany Lions to the third round.
