Penn State won its fourth consecutive game Sunday and completed its first series sweep of the season.
According to a report by NFL Network's Tom Pelissero, Wade signed with Pittsburgh in the minutes following the draft.
Fries is the second Nittany Lion offensive lineman selected in the 2021 NFL Draft.
Toney was drafted in the seventh of this year's draft, making him the fourth Nittany Lion off the board thus far.
The menacing 6'8", 340-pound tackle is the second offensive lineman to join Penn State's class of 2022.
McPhearson played in 24 games over two seasons as a Nittany Lion before transferring to Texas Tech to finish out his college career.