The Nittany Lions have won 35 straight matches over the Scarlet Knights.
Gavin McKenna scored his first goal at Pegula Ice Arena in the comeback victory.
The Nittany Lions scored four goals in the first five minutes.
The Nittany Lions remain undefeated through nine games.
"I know it's something that we are constantly working on, but I still think we have a lot of work to do."
Yanic Konan Niederhauser scored four points in his NBA debut with the Los Angeles Clippers on Wednesday.