After a slow start, Penn State scored five unanswered against the Leopards.
The Nittany Lions opened Big Ten play with the win.
Junior Maddy Christian gave Penn State the lead late in the second period.
Amelia White's early goal was not enough to overcome the Hawkeyes.
Penalties were an issue for both sides.
The Pistons will be Lamar Stevens' fourth team in his five-year NBA career.