Dylan Lugris delivered the game-winning goal in round four of the shootout over the No. 1 team in the nation.
Captain Tessa Janecke tied the all-time points leader with an assist to Abby Stonehouse.
The Nittany Lions kicked off the 2025 campaign with a loss in Chicago, Illinois.
Penn State falls to 1-9-1 in Big Ten conference play.
Katie DeSa recorded her fourth shutout of the season.
Gabby Elliott's 26 points weren't enough for Penn State to overcome two separate 15-point deficits against the Ducks.