The 5-3 victory marks Penn State's first victory in Yost Ice Arena since 2019 and first conference win this campaign.
The Nittany Lions took their final home game in dominant fashion.
Erica Dambach clinched her seventh consecutive NCAA Tournament Sweet Sixteen berth, which is tied for the longest active streak in Division I women's soccer.
The blue and white showed flashes of momentum but ultimately could never match the Wolverines' answers during the first game of the weekend series.
The Nittany Lions extended their three-game win streak as the season begins to wind down.
Qudas Wahab recorded his second double-double of the season, totaling 14 points and 12 rebounds.