The Nittany Lions survived a tense battle on the road to stay unbeaten through 11 games.
Three goals in the final 25 minutes of play lifted the Nittany Lions over the Bison after conceding a goal in the second minute.
The "Academic Heisman" is awarded to the most academically high-performing college football player in the country.
The Nittany Lions are now 5-1-2 in overall play and 2-0 in conference matchups.
The Nittany Lions remain undefeated through 10 games, including two ranked opponents.
Shakes earned his third Big Ten weekly award of the season, while Mangione earned his first.