The Nittany Lions will play in the Big Ten Tournament semifinals on Thursday.
Two comeback attempts fell short on Saturday and Sunday.
The series concluded with Senior Day celebrations for six Nittany Lions.
Penn State will play Maryland in the next round in Columbus.
Penn State fought to secure the last-minute win and move on to the semifinals.
Last spring, Brown entered the transfer portal but eventually chose to return to Happy Valley and commit to head coach Mike Rhoades.