A go-ahead Lexie Black home run was almost enough for the Nittany Lions, however, Indiana pulled off a walk-off victory in nine innings Thursday afternoon.
Penn State will join an eight-team field featuring Boise State, Florida Atlantic, Iowa State, Texas A&M, VCU, Virginia Tech, and Butler
Penn State extended its losing streak to four games, its longest of the season.
In the teams' first meeting this season, Melody Coombs engineered a timely bunt to bring home Lilia Crouthamel and secure a walk-off win to move on to the conference tournament quarterfinal game.
Mitchell chose Penn State over offers from Arkansas, BYU, and Oklahoma State.
Emily Maddock was the lone Nittany Lion to earn a nod to the All-Big Ten first team after an impressive season.