This will mark Iowa's second White Out appearance in Beaver Stadium and its first since 2009. The game will kickoff at 8 p.m. and be broadcast on CBS.
The trophy honors accomplishments by collegiate defenders on and off the field.
Scruggs was with the Nittany Lions for six years and started in his final two seasons.
Penn State holds a 48-9-2 all-time record against West Virginia, and September's matchup marks the first time the teams have faced off since 1992.
After Clifford's post-draft arrival in Green Bay, the former Penn State quarterback nabbed the old locker of an NFL legend.
Reid's pickup comes just one day after he was released by the Atlanta Falcons.