Roman Bravo-Young, Carter Starocci, Aaron Brooks, and Levi Haines all took home individual Big Ten titles on Sunday.
After forcing a third game in the series and striking first on Sunday night, the Nittany Lions couldn't respond to three Buckeye goals.
Beau Bartlett and Shayne Van Ness are moving on to session four to compete for third place.
Camren Wynter hit his second-straight game winner to help the Nittany Lions land at a .500 conference-win percentage.
Fresh off their first-ever CHA Tournament championship, the Nittany Lions will take on Quinnipiac in the opening round of the NCAA Tournament on Thursday, March 9.
Kylee Lingenfelter's record-breaking 17-strikeout performance led the Nittany Lions to sweep Delaware, Norfolk State, and Hampton.