Penn State heads into the bye week with a dreadful 0-4 conference record.
Former Penn State star Micah Parsons recorded his first career three-sack game.
Brohm is 4-0 against top-five teams in the regular season.
Penn State battled back in the second half but could not find the win.
The Nittany Lions are 8-0 so far in the season.
The Nittany Lions were the preseason No. 2 in the country.