The Nittany Lions rallied from a two-goal deficit in the third period.
The Nittany Lions are now 30-2 all-time against the Wolverines at Rec Hall.
Penn State breezed past the Blue Devils to move onto the Round of 32 in the NCAA Tournament.
Penn State put up its fourth-largest margin of victory in program history.
Tickets for the event are on sale now.
Harbaugh's suspension comes on the back of a probe into a sign stealing by the Wolverines.