Brohm is 4-0 against top-five teams in the regular season.
Penn State battled back in the second half but could not find the win.
The Nittany Lions are 8-0 so far in the season.
The Nittany Lions were the preseason No. 2 in the country.
The Nittany Lions re-join the top five after sweeping LIU over the weekend.
The Big Ten bout will be nationally televised on FOX for the fourth consecutive year.