The Nittany Lions outshot Clarkson 81-48.
A 73rd minute go-ahead goal from captain Peter Mangione was the difference as the Nittany Lions gave Northwestern its first loss.
Sophia Gladieux scored two goals for her fourth multi-goal game of the season.
UMass is 1-6 this season, with its lone win being a 41-30 victory over New Mexico State.
The Nittany Lions have dominated in the secondary, holding some of the best passing statistics in the nation.
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