Brianna Brooks scored three times as the Nittany Lions looked to secure their second consecutive CHA regular season title.
The absence of John Kerr, Michael Valenzi, and Tony Ezeonu was no problem for Penn State as it flexed depth all match long.
The Nittany Lions were shutout for the second night in a row.
Matt Traynor tallied six goals in the Nittany Lions' dominant outing.
Sanderson has a record of 200-16-2 as Penn State's head coach.
The win gave Cael Sanderson his 200th as the head coach of the Nittany Lions.
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