A 17-point third quarter powered Penn State to a 41-13 win over Northwestern.
Hamler joins the Colts after three years with the Denver Broncos.
Wide receiver Malick Meiga and Trey Wallace could both miss Saturday's matchup.
The Nittany Lions will kick off against the Wildcats at noon on the Big Ten Network.
The Nittany Lions have gone 9-0 in their last nine sets to extend their conference win streak to three.
The Huskies spoiled Penn State's banner night and home opener with a shutout of the Nittany Lions.
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