Penn State overcame a sluggish first half with 31 points and an interception in the second.
Potts was forced to come into the Nittany Lions' matchup with Northwestern after an injury put Allen on the sideline.
A 17-point third quarter powered Penn State to a 41-13 win over Northwestern.
Hamler joins the Colts after three years with the Denver Broncos.
Wide receiver Malick Meiga and Trey Wallace could both miss Saturday's matchup.
The Nittany Lions will kick off against the Wildcats at noon on the Big Ten Network.
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